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"GOOD HEALTH assigns a premium value to brain support. True brain power comes from knowledge in action. MEND Solutions™ relies on Nature's purest ingredients. They are the ways and means for a healthy brain and rich life. When life presents opportunities and challenges use these tools to increase your chances of success."

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Founder and President

Most Americans can't do it
because they aren't getting any METHYLCOBALAMIN

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Stress, obesity, infections, hormones, or alcohol
Can INCREASE your risk of

1. Cancer
2. Dementia
3. Depression
4. Heart disease

1. Cancer
2. Dementia
3. Depression
4. Heart disease

You may want to get all the Vitamin B-12 and folate you need from what you're eating or by taking your multivitamin. But, you're really NOT getting what you need.

If you want to combat the risks of stress, obesity, infections, hormones, or alcohol, you need to learn about medical breakthroughs that takes you beyond homocysteine and cholesterol. They empower your efforts to stay healthy. They help you make the most of your God-given abilities, maximizing your performance.

Methylcobalamin is the most potent form of Vitamin B12 found in nature. We need methylcobalamin for the healthy development and sustenance of our circulatory, immune and nervous systems.

Eggs, dairy products, fish and meat, especially organ meat like liver, are good sources of Vitamin B-12. In fact, meals incorporating large amounts of liver represented the main treatment for Vitamin B-12 deficiency in the past.

Methylcobalamin is the only active form of Vitamin B-12 in the brain outside the mitochondrion. The liver must convert cyanocobalamin to methylcobalamin in order for Vitamin B-12 to do its biochemical work in the brain. When the complex conversion of cyanocobalamin is not completed, the brain is robbed of the benefits of methylcobalamin. Cyanocobalamin is a by-product of Vitamin B-12 charcoal extraction. Scientific methods led people to believe that cyanocobalamin, not methylcobalamin was the naturally occurring form of Vitamin B-12. Cyanide in the charcoal replaces the methyl group in much the same way as it does in the body of a cigarette smoker. Vitamin B-12 requires the assistance of Intrinsic Factor to enter the body from the small intestine. Without Intrinsic Factor, dietary Vitamin B-12 or B-12-containing supplements go unabsorbed.

Autoimmune reactions and diseases sometimes destroy the stomach's parietal cells that produce Intrinsic Factor. Pernicious anemia results from this destructive process. More rarely, pernicious anemia develops when the body makes antibodies against the binding site of Intrinsic Factor. The antibodies rob Vitamin B-12 of the binding spot on Intrinsic Factor as it tries to make its way into the small intestine. Monthly injections of Vitamin B-12 can correct the anemia, immune and neurological problems that sneak up on people with pernicious anemia.

Surveys of depressed patients indicate nearly one-third of them do not receive enough folate or Vitamin B-12. It is extremely important to take Vitamin B-12 when taking folate supplements. Without Vitamin B-12 supplementation, worse physical problems might develop during folate supplementation.

Small amounts of Vitamin B-12 are absorbed directly through the mucosal tissue of the mouth. This discovery led to the development of Vitamin B12 lozenges and sprays. When Vitamin B-12 is absorbed in the mouth, it goes into the blood and then to the enzymes that require Vitamin B-12 as a coenzyme. With other forms of Vitamin B-12, the liver must use its enzyme systems to produce methylcobalamin.

With increased availability of methylcobalamin, medical research has shown that methylcobalamin has important benefits not seen with cyanocobalamin. It acts to reverse nerve damage and promote nerve cell regeneration.

Methylcobalamin plays a key role in sleep. It helps the brain fill up its neurotransmitter "gas tank" when neurotransmitters are produced from amino acids. Similarly, depression also improves more quickly and completely when patients take methylcobalamin. Depression also can worsen even while using antidepressants if a restrictive diet is started to lose weight. A diet can run the neurotransmitter "gas tank" dry.

Homocysteine has emerged on center-stage as a biochemical culprit associated with vascular and brain disease. Methylcobalamin and 5-methyl-tetrahydrofolate are crucial to the elimination of homocysteine. Vitamin supplementation reduces the chances of building up levels of homocysteine associated with stress.

Clinical experience and scientific research have clearly established the importance of Vitamin B-12. The discovery of Vitamin B-12 was considered so monumental that the responsible researchers were honored with the Nobel Prize. Recent discoveries have demonstrated the value of using methylcobalamin for improvement in the cardiovascular, immune and nervous systems.*

*These statements have not been evaluated by the Food and Drug Administration. Our products are not intended to diagnose, treat, cure or prevent any disease. All references made for the use of our products are intended for nutritional support to improve normal physiological states and conditions. Any impression made that our products are to be used to treat a disease state or condition should be considered inadvertent and coincidental. Our products are intended to supplement balanced diets.

REFERENCES

Baldessarini, R. (1987) "Neuropharmacology of S-adenosyl-L-methionine." JAMA, 83: 95-103.

Bottiglieri, T. (1997) "Folate, vitamin B12 and neuropsychiatric disorders." Nutr. Rev., 54: 382-390.

Bottiglieri, T., et al. (1990) "Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine." J. Neurol. Neurosurg. Psychiatry, 53: 1096-98.

Crellin, R., Bottiglieri, T., and Reynolds, E.H. (1995) "Folates and psychiatric disorders." Drugs, 45: 623-636.

Fava, M., et al. (1997) "Folate, B12, and homocysteine in major depression." Am. J. Psychiatry, 154: 426-428.

Ikeda, T., et al. (1993) "Treatment of Alzheimer-type dementia with intravenous mecobalamin." Clin. Therap., 14: 426-437.

Kaju, R., et al. (1998) "Effects of ultra high dose methylcobalamin on compound action potentials in amyotrophic lateral sclerosis: a double-blind controlled study." Muscle Nerve, 21: 1775-1778.

Kuzminski, A.M., et al. (1998) "Effective treatment of cobalamin deficiency with oral cobalamin." Blood, 92: 1191-1198.

Loehrer, F.M., et al. (1996) "Low whole-blood S adenosylmethionine and correlation with 5-methyltetrahydrofolate and homocysteine in coronary artery disease." Arterioscler. Thrombo-sis Biol., 16: 727-733.

Mayer, G., et al. (1996) " Effects of B12 on performance and circadian rhythms in normal subjects." Neuropsychopharm., 15: 456-464.

Ohta, T., et al. (1991) "Treatment of persistent sleep-wake schedule disorder in adolescents with methylcobalamin." Sleep, 14: 414-418.

Okawa, M. et al. (1990) "Vitamin B12 treatment for sleep-wake rhythm disorders." Sleep, 13: 15-23.

Sakane, T., et al. (1982) "Effects of methyl B12 on in vitro immune functions of human T lymphocytes." Experientia, 48: 716-720.

Watanaabe, T., et al. (1994) Ultra high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy." J. Neurol. Sci., 122: 140-143.

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